Experience

 

Brillance Sp. z o.o. has been supporting Sponsors (pharmaceutical, biotech, and medical device companies) in conducting clinical trials in Poland, the Czech Republic, and Slovakia since 2004. 

 

22+
years of clinical trial experience
268+
projects delivered since inception
10+
years of experience in medical device clinical research
Experience by trial phase
 
  • Hemato-oncology: Phases I - III
  • Other therapeutic areas: Phases II - IV

Our project portfolio – therapeutic areas

 

Portfolio by key therapeutic areas
Legend
 
Oncology & hemato-oncology
28%
 
Rare & specialist diseases
23%
 
Respiratory diseases & allergology
13%
 
Cardiology
12%
 
CNS / neurology / psychiatry
11%
 
Metabolism / endocrinology
7%
 
Rheumatology
6%

Selected recruitment outcomes: Poland, the Czech Republic, Slovakia.

 

 

Therapeutic experience and indications

 

Oncology
Phases II-IV
  • Breast cancer
  • Colorectal cancer
  • Prostate cancer
  • Endometrial cancer
  • Head and neck cancers
  • Liver cancer
  • Hepatocellular carcinoma (HCC)
  • Renal cell carcinoma (kidney cancer)
  • Pancreatic cancer
  • Melanoma
  • Lung cancer vaccine
  • Non-small cell lung cancer (NSCLC)
  • Cancers of the tongue and soft palate
  • Oral cavity and soft palate cancer
  • Cutaneous squamous cell carcinoma (cSCC)
  • Squamous cell carcinoma of the head and neck (SCCHN)
  • Non–muscle-invasive bladder cancer (NMIBC)
Hemato-oncology
Phases I-III
  • Chronic myeloid leukemia (CML)
  • Chronic lymphocytic leukemia (CLL)
  • Myelodysplastic syndromes (MDS)
  • Multiple myeloma (MM)
  • Waldenström macroglobulinemia (WM)
  • Lymphoplasmacytic lymphoma (LPL)
  • Non-Hodgkin lymphomas
  • Follicular lymphoma (FL)
  • Small lymphocytic lymphoma (SLL)
  • Marginal zone lymphoma (MZL)
  • Mantle cell lymphoma (MCL)
  • Diffuse large B-cell lymphoma (DLBCL)
  • High-grade B-cell lymphoma (HGBL)
  • Primary CNS lymphoma (PCNSL)
  • Secondary CNS lymphoma (SCNSL)
  • Primary cutaneous diffuse large B-cell lymphoma (DLBCL)
Cardiology
Phases II-IV
  • Arterial hypertension (including pediatric)
  • Pulmonary hypertension
  • Hyperlipidemia
  • Atherosclerosis in ischemic heart disease (IHD)
  • Coronary artery disease (CAD)
  • Ischemic heart disease (IHD)
  • Angina pectoris
  • Acute coronary syndrome (ACS)
  • ACS in patients with type 2 diabetes (T2D)
  • Myocardial infarction (MI)
  • Myocardial infarction with cardiogenic shock (MI + CS)
  • Percutaneous coronary intervention (PCI)
  • Revascularization
  • Chronic heart failure
  • Acute heart failure
  • Newly diagnosed atrial fibrillation
  • Anticoagulation therapy in atrial fibrillation
  • Mitral regurgitation
  • Transcatheter mitral valve repair
  • Myocardial injury after non-cardiac surgery (MINS)
  • Systemic vasculitis
Neurology / Psychiatry
Phases II-IV
  • Bipolar disorder
  • Depression
  • Premenstrual dysphoric disorder (PMDD)
  • Alzheimer’s disease (AD)
  • Amyotrophic lateral sclerosis (ALS)
    Epilepsy
  • Multiple sclerosis (MS), including pediatric relapsing–remitting disease (RMS)
  • Huntington’s disease (HD)
  • Myasthenia gravis (MG)
  • Postherpetic neuralgia (PHN)
  • Pediatric mitochondrial disease
Metabolism / Endocrinology / Diabetology
Phases II-IV
  • Type 2 diabetes (T2D)
  • Type 1 diabetes (T1D)
  • Impaired glucose tolerance (IGT)
  • Cushing’s syndrome
  • Hypopituitarism / growth hormone deficiency (GHD)
Nephrology
Phases II-IV
  • Anemia in chronic kidney disease (CKD)
  • Chronic kidney disease (CKD)
  • End-stage renal disease (ESRD)
Respiratory Diseases
Phases II-IV
  • Asthma
  • Chronic obstructive pulmonary disease (COPD)
  • Pneumonia
  • Cystic fibrosis
Allergology / Immunology
Phases II-IV
  • Allergic rhinitis (AR)
  • House dust mite–induced allergic rhinitis
  • Allergic rhinitis with or without asthma (children and adults)
  • Allergic rhinitis and conjunctivitis
  • Allergic rhinitis and conjunctivitis with asthma
  • Bronchial asthma
  • Eosinophilic asthma
  • House dust mite–induced asthma
  • Timothy grass pollen allergy
  • Birch pollen allergy (pediatric population)
  • Hereditary angioedema (HAE)
  • Primary immunodeficiencies / virology
Otolaryngology (ENT)
Phases II-IV
  • Sinusitis / rhinosinusitis
  • Otitis media (pediatric)
  • Vertigo / dizziness (lightheadedness)
  • Tinnitus
Gastroenterology
Phases II-IV
  • Crohn’s disease (CD)
  • Postoperative ileus (POI)
  • Exocrine pancreatic insufficiency 
  • Liver injury
  • Primary sclerosing cholangitis (PSC)
  • Nonalcoholic steatohepatitis (NASH)
Rheumatology
Phases II-IV
  • Rheumatoid arthritis (RA)
  • Osteoporosis / osteopenia (postmenopausal)
  • Juvenile idiopathic arthritis (JIA)
  • Gout
  • Cutaneous lupus
Vaccines / Infectious Diseases
Phases II-IV
  • Influenza vaccine (including pediatric population)
  • Combined measles, mumps, rubella, and varicella vaccine (MMRV)
  • Pneumococcal vaccine
  • Herpes zoster (shingles) vaccine
  • Herpes zoster in patients after bone marrow transplantation
  • Hepatitis B virus infection (HBV)
  • Hepatitis C virus infection (HCV)
  • Antiviral therapies (influenza)
Dermatology
Phases II-IV
  • Distal lateral subungual onychomycosis (DLSO)
  • Nail psoriasis
Gynecology
Phases II-IV
  • Mastodynia
  • Recurrent vulvovaginal candidiasis (RVVC)
Hematology
Phases II-IV
  • Anticoagulant therapies
  • Hemophilia A
Ophthalmology
Phases II-IV
  • Glaucoma
  • Choroidal neovascularization secondary to age-related macular degeneration (AMD)

Medical Devices - experience (10+ years)

 

We support clinical projects of medical devices and MedTech solutions – from pilot projects, through pivotal studies, to post-market clinical investigations including studies in cardiology, orthopedics, surgery and diagnostics. We provide end-to-end Sponsor support, with a strong focus on quality, efficient communication, operational excellence and inspection readiness.

 

Example areas of medical device clinical investigations
  • Cardiology (including interventional cardiology and devices) – e.g., revascularization, pulmonary hypertension, transcatheter mitral valve repair
  • Orthopedics / surgery - e.g., femoral stem revision procedures
  • Diagnostics and technologies supporting clinical decision-making
  • Studies: pilot, pivotal, post-market (device-based)
How we support Sponsors
  • End-to-end study support from initiation through close-out (start-up → conduct → close-out)
  • Work performed in accordance with ISO 14155 (GCP for medical devices) and an “inspection-ready” approach
  • Understanding of MedTech project specifics: clinical pathway, procedure organization, and site realities
  • Site selection based on actual procedural volumes and patient access + efficient site activation
  • Strong focus on data and documentation quality + practical team training (sites/CRAs)
  • Flexible resourcing and tailored project support + an experienced CRA team